Medical science has been one of the most fascinating field in the industry. It has answered several questions regarding medical diseases and most importantly discovered several treatments for the many physical diseases of human. Clodronate liposome for example, are one of those remarkable discoveries which could play a great role in medicine.
Macrophages basically is the core of the immune system. Macrophage has two functions and that includes natural immune reaction and regulating non phagocytic cells. More so, these cells plays a major role in immune responses and immunity. It will automatically defends the body, through phagocytosis of different microbes and parasite.
Clodronate liposome is a type of component whose mechanism of action focuses on the suppression of the immune system. As what is popularly known, the immune system is important to the body as this is what defends the body from certain bacterial and viral infection. That is true of course, however the immune system could also be a culprit to the human's body.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.
During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
More so as it reduces phagocytic cells, it is also believed to inhibit tumor growth. In some cancer research, this component has shown a significant depletion of Kupffer cells, a significant cancer cell especially to liver cancer resulting to increased plasma absorption and antitumor effect over some chemotherapeutic drugs.
During cancer, clodronate liposome helps by improving anti tumor effects of anti tumor drugs and effectively increase plasma absorption. This phenomenon may not be able to cure the disease itself, however the disease will be properly managed by then. There's no doubt that such component holds a great relevance in medicine, especially disease treatment. Certain countries such as Australia, Canada, Italy and the United Kingdom has allowed such treatment to be used by humans.
Macrophages basically is the core of the immune system. Macrophage has two functions and that includes natural immune reaction and regulating non phagocytic cells. More so, these cells plays a major role in immune responses and immunity. It will automatically defends the body, through phagocytosis of different microbes and parasite.
Clodronate liposome is a type of component whose mechanism of action focuses on the suppression of the immune system. As what is popularly known, the immune system is important to the body as this is what defends the body from certain bacterial and viral infection. That is true of course, however the immune system could also be a culprit to the human's body.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.
During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
More so as it reduces phagocytic cells, it is also believed to inhibit tumor growth. In some cancer research, this component has shown a significant depletion of Kupffer cells, a significant cancer cell especially to liver cancer resulting to increased plasma absorption and antitumor effect over some chemotherapeutic drugs.
During cancer, clodronate liposome helps by improving anti tumor effects of anti tumor drugs and effectively increase plasma absorption. This phenomenon may not be able to cure the disease itself, however the disease will be properly managed by then. There's no doubt that such component holds a great relevance in medicine, especially disease treatment. Certain countries such as Australia, Canada, Italy and the United Kingdom has allowed such treatment to be used by humans.
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